Influence of high intensity focused ultrasound reflected from a soft-tissue/bone interface on the temperature rise and lesion formation

Abstract

Abstract The influence of high-intensity focused ultrasound (HIFU) reflected from a soft-tissue/bone interface on the temperature rise and lesion formation was theoretically and experimentally investigated in a soft-tissue/bone phantom. The acoustic intensities and the HIFU-induced temperature rises at the focal and the pre-focal regions were numerically simulated without and with the bone. Thermal ablation experiments in a soft-tissue/bone phantom were performed to validate the simulation results. It was found that the presence of a soft-tissue/bone interface in the HIFU beam path may enhance heating leading to the growth of the thermal lesion toward the HIFU source and the bone.