Plasmonic chip application to enhanced fluorescence immunosensing and promotion of photochemical reaction

Abstract

Abstract Plasmonic chip is the substrate with a wavelength scale-periodic pattern covered with thin metal films in which the electric field enhanced by the grating-coupled surface plasmon resonance can be used for exciting fluorescence molecules and for promoting photochemical reaction. The enhanced fluorescence has been applied to the sensitive detection of target molecule in immunosensors. To improve the detection sensitivity, optimal structure of the plasmonic chip has been studied. In this paper, epidermal growth factor receptor, α-fetoprotein, and candida mannan detection and breast cancer cells and neurons observation are reported. Further, the nanoantenna effect formed by superposition of the propagating waves in the plasmonic pattern is also studied for single molecule detection. As for applying the enhanced electric field to the photochemical reaction, crystallization of lysozyme and diarylethene and preparing capture interface in immunosensor are also reported. Plasmonic chip application and its future development are introduced.