Evaluation and bioparticle density correlation analysis of extended gate HEMT sensors for biological detection from microscopic view

Abstract

Abstract In this letter, we focus on the relationship between modification bioparticle density (N) and biological regulation ability in extended gate HEMT (EG-HEMT) biosensors. By analyzing, we demonstrate that under the same gate electrodes size (S g) and concentration, N is exponentially related to the area of sensing regions (y) and has fixed exponential magnification −0.65 ± 0.05. This formula had been demonstrated to have perfect universality when testing protein and small molecules. Finally, we apply N to the structural design of EG-HEMT biosensors and projected that 10 y structure has both high biological regulation ability of biosensors and efficient utility of chips.