Methyl jasmonate and diphenyl diselenide attenuate diethylnitrosamine and carbon tetrachloride-induced nephrotoxicity in rats via modulation of inflammation and oxidative stress processes

Author:

O.A Adedoyin,B.O Opeyemi,O.A Adaramoye

Abstract

The pathogenesis of toxicity-mediated renal injury has been linked to reactive oxygen species. Therefore, intervention with antioxidant agents as part of therapeutic strategies is necessary. This study investigated the modulatory effects of Diphenyldiselenide (PhSe)2 and Methyl Jasmonate (MJ) against Diethylnitrosamine (DEN) and Carbon tetrachloride (CCL4)-induced nephrotoxicity in male Wistar rats. Forty-eight (48) rats were assigned into six groups of eight animals each. Group 1 served as control, Group 2 received DEN (100mg/kg) + CCL4 (0.5mg/kg), Group 3 received [DEN+CCL4] and treated with MJ (50 mg/kg), Groups 4 and 5 received [DEN+CCL4] and treated with (PhSe)2 (5 mg/kg and 10 mg/kg), and Group 6 received [DEN+CCL4] and treated with quercetin (50mg/kg). Administration of DEN and CCL4 increased serum urea, creatinine and kidney injury molecule-1 (KIM-1) by 97%, 62% and 73%. Furthermore, activities of glutathione-S-transferase, superoxide dismutase and catalase significantly (P<0.05) decreased in [DEN+CCL4] rats. The BCL-2 associated X, caspases -3 and -9 increased in rats administered-[DEN+CCL4]. In addition, TNF-α increased by 117%, myeloperoxidase and nitric oxide level increased by 385% and 65%, respectively in [DEN+CCL4]-administered rats. Histology showed mild vascular congestion and infiltration of inflammatory cells in interstitial spaces in [DEN+CCL4] rats. Interestingly, treatment with methyl jasmonate and diphenyl diselenide attenuated kidney function markers, reduced tissue inflammation and apoptosis status of [DEN+CCL4]-rats. Methyl jasmonate and diphenyldiselenide abate nephrotoxicity caused by combined administration of DEN- and CCL4- via induction of antioxidative and anti-inflammatory activities.

Publisher

Nigerian Journal of Pure and Applied Sciences

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3