Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

Author:

Egnatchik Robert A.12,Brittain Evan L.3,Shah Amy T.4,Fares Wassim H.5,Ford H. James6,Monahan Ken3,Kang Christie J.7,Kocurek Emily G.7,Zhu Shijun7,Luong Thong7,Nguyen Thuy T.8,Hysinger Erik9,Austin Eric D.10,Skala Melissa C.411,Young Jamey D.212,Roberts L. Jackson8,Hemnes Anna R.7,West James47,Fessel Joshua P.7811

Affiliation:

1. Children’s Medical Center Research InstituteUniversity of Texas SouthwesternDallasTXUSA

2. Department of Chemical and Biomolecular EngineeringVanderbilt UniversityNashvilleTNUSA

3. Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular CenterDepartment of MedicineVanderbilt University Medical CenterNashvilleTNUSA

4. Department of Biomedical EngineeringVanderbilt UniversityNashvilleTNUSA

5. Section of Pulmonary, Critical Care & Sleep MedicineDepartment of MedicineYale UniversityNew HavenCTUSA

6. Division of Pulmonary Diseases and Critical Care MedicineDepartment of MedicineUniversity of North Carolina Chapel HillChapel HillNCUSA

7. Division of AllergyPulmonary and Critical Care MedicineDepartment of MedicineVanderbilt University Medical CenterNashvilleTNUSA

8. Department of PharmacologyVanderbilt UniversityNashvilleTNUSA

9. Division of Pulmonary MedicineChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA

10. Division of Pulmonary MedicineDepartment of PediatricsVanderbilt University Medical CenterNashvilleTNUSA

11. Department of Cancer BiologyVanderbilt UniversityNashvilleTNUSA

12. Department of Molecular Physiology and BiophysicsVanderbilt UniversityNashvilleTNUSA

Funder

National Institutes of Health

American Heart Association

Actelion Pharmaceuticals

National Center for Advancing Translational Sciences

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

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