Feasibility of Azithromycin Prophylaxis During a Pertussis Outbreak Among Healthcare Workers in a University Hospital in Paris

Author:

Giugliani Camila,Vidal-Trécan Gwenaëlle,Traore Souleymane,Blanchard Hervé,Spiridon Gabriela,Rollot Florence,Launay Odile,Gorodestski Myriam,Marande Jean-Luc,Vinsonneau Christophe,Guillevin Loïc,Salmon-Céron Dominique

Abstract

The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Microbiology (medical),Epidemiology

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