Clinical and Molecular Epidemiology of Human Rhinovirus C in Children and Adults in Hong Kong Reveals a Possible Distinct Human Rhinovirus C Subgroup

Author:

Lau Susanna K. P.1234,Yip Cyril C. Y.4,Lin Ada W. C.5,Lee Rodney A.6,So Lok-Yee7,Lau Yu-Lung8,Chan Kwok-Hung4,Woo Patrick C. Y.1234,Yuen Kwok-Yung1234

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases

2. Research Centre of Infection and Immunology

3. Carol Yu Center for Infection

4. Department of Microbiology, The University of Hong Kong, Departments of

5. Medicine

6. Pathology, and

7. Pediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, and

8. Department of Pediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong

Abstract

Abstract BackgroundA novel human rhinovirus (HRV) species, HRV-C, was recently discovered, but its clinical features and epidemiology, compared with HRV-A and HRV-B, remains poorly understood, especially in adults MethodsOne thousand two hundred nasopharyngeal aspirate samples obtained from hospitalized children and adults during a 1-year period were subject to reverse-transcriptase polymerase chain reaction to detect HRV. The clinical and molecular epidemiology of the 3 HRV species was analyzed ResultsHRVs were detected in 178 (29.7%) of 600 nasopharyngeal aspirate samples from children and 42 (7%) of 600 nasopharyngeal aspirate samples from adults. HRV-A was most prevalent (n=111), followed by HRV-C (n=91) and HRV-B (n=18). Although upper respiratory tract infection was the most common presentation in children, 8 (62%) of the 13 adults with HRV-C infection had pneumonia, compared with 6 (27%) of the 22 adults with HRV-A infection (P<.05). Wheezing episodes were also more common among individuals with HRV-C (37%) and HRV-A (20%) infection than among those with HRV-B (0%) infection (P<.05). Clinical and molecular data analysis revealed HRV-C as a frequent cause of community and institutionalized outbreaks. A diverse set of HRV-C genotypes was circulating throughout the year, among which a potential distinct subgroup of strains was observed ConclusionHRV-C is associated with pneumonia in adults and outbreaks of respiratory infections requiring hospitalization. A potential novel HRV-C subgroup was identified

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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