BK Channels in Rat and Human Pulmonary Smooth Muscle Cells are BK α‐β 1 Functional Complexes Lacking the Oxygen‐Sensitive Stress Axis Regulated Exon Insert

Author:

Detweiler Neil D.1,Song Li1,McClenahan Samantha J.1,Versluis Rachel J.1,Kharade Sujay V.2,Kurten Richard C.3,Rhee Sung W.1,Rusch Nancy J.1

Affiliation:

1. Department of Pharmacology and ToxicologyCollege of MedicineUniversity of Arkansas for Medical SciencesLittle RockArkansasUSA

2. Department of AnesthesiologySchool of MedicineVanderbilt UniversityNashvilleTennesseeUSA

3. Department of Physiology and Biophysics and Department of PediatricsCollege of MedicineUniversity of Arkansas for Medical SciencesArkansas Children's Hospital Research InstituteLittle RockArkansasUSA

Funder

National Heart, Lung, and Blood Institute

American Heart Association

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

Reference42 articles.

1. Dysfunctional voltage‐gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension;Yuan JX‐J;Circulation,1998

2. Chronic hypoxia inhibits KV channel gene expression in rat distal pulmonary artery;Wang J;Am J Physiol,2005

3. Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: Pharmacotherapeutic implications;Burg ED;Br J Pharmacol,2008

4. In vivo gene transfer of the O2‐sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats;Pozeg ZI;Circulation,2003

5. Oxygen tension modulates the expression of pulmonary vascular BKCa channel α‐ and β‐subunits;Resnik E;Am J Physiol,2005

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