Abstract
Purpose: To evaluate the levels of salusin-beta (β-SAL) in the serum in patients with age-related macular degeneration (ARMD). Methods: Our study was designed as a controlled comparative clinical study. The β-SAL levels in serums of age and sex-matched 20 healthy volunteers as controls (Group 1), 20 patients with dry-age related macular degeneration (d-ARMD) (Group 2) and 20 patients with wet-age related macular degeneration (w-ARMD) (Group 3) were measured with the enzyme-linked immunosorbent assay (ELISA) method. Results: In our study, it was found that age and gender didn’t show a statistically significant difference among the study groups (p > 0. 05). The mean serum β-SAL levels in Group 1, Group 2 and Group 3 were 1372,17 ± 1126.69 pg/mL; 1423,71 ± 1196.84 pg/mL and 940,57 ± 1092.05 pg/mL, respectively. Although the meanβ-SAL levels in w-ARMD seem numerically lower than both the control and d-ARMD groups, this difference among the study groups was not statistically significant (p > 0.05). Conclusion: Our study suggests that β-SAL levels in the patients with ARMD and healthy controls were not different than each other. Further studies with large numbers may reveal possible relationships between β-SAL and ARMD.
Publisher
Heighten Science Publications Corporation
Reference40 articles.
1. 1. Ambati J, Ambati BK, Yoo SH, Ianchulev S, Adamis AP. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 2003; 48: 257-293. PubMed: https://pubmed.ncbi.nlm.nih.gov/12745003/
2. 2. Ratnapriya R, Chew EY. Age-related macular degeneration-clinical review and genetics update. Clin Genet. 2013; 84: 160-166. PubMed: https://pubmed.ncbi.nlm.nih.gov/23713713/
3. 3. Scholl HP, Fleckenstein M, Charbel Issa P, Keilhauer C, Holz FG, et al. An update on the genetics of age-related macular degeneration. Mol Vis. 2007; 13: 196-205. PubMed: https://pubmed.ncbi.nlm.nih.gov/17327825/
4. 4. Moschos MM, Nitoda E, Chatziralli IP, Demopoulos CA. Age-Related Macular Degeneration: Pathogenesis, Genetic Background, and the Role of Nutritional Supplements. J Chem. 2014; 2014: Article ID 317536. 9.
5. 5. Patel M, Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol. 2008; 30: 97-110. PubMed: https://pubmed.ncbi.nlm.nih.gov/18299834/
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