Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units-Reference-Cited by-同舟云学术

Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units

Published:2023-06 Issue:1 Volume:18 Page:86-91
ISSN:1857-1727
Container-title:Chemistry Journal of Moldova
language:
Short-container-title:Chem. J. Mold.

Author:

Blaja Svetlana^ORCID,Lungu Lidia^ORCID,Ciocarlan Alexandru^ORCID,Vornicu Nicoleta^ORCID,Aricu Aculina^ORCID

Abstract

Synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment has been reported. The structures of the new synthesized compounds were confirmed using IR and 1H, 13C, and 15N NMR spectroscopy. The in vitro antifungal and antibacterial activities of the mentioned compounds have been evaluated. Results of this study have shown that the 1,3,4-thiadiazole-2-imine has excellent activity against tested strains of fungi and species of bacteria at minimum inhibitory concentration values of 0.125 and 2.5 μg/mL, respectively.

Publisher

Moldova State University

Subject

Process Chemistry and Technology,Environmental Chemistry,General Chemistry

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