Serum vitamin C status of people in New South Wales: retrospective analysis of findings at a public referral hospital

Author:

Bhattacharyya Puja12,Schemann Kathrin3,Min San San45,Sullivan David R45,Fuller Stephen J16ORCID

Affiliation:

1. Sydney Medical School the University of Sydney Sydney NSW

2. Blacktown Hospital Blacktown NSW

3. The University of Sydney Sydney NSW

4. Royal Prince Alfred Hospital Sydney NSW

5. NSW Health Pathology Sydney NSW

6. Nepean Hospital Penrith NSW

Abstract

AbstractObjectivesTo examine the relationship between vitamin C status and demographic factors in New South Wales on the basis of serum vitamin C test results undertaken at the central pathology laboratory in Sydney, and to assess associations with age, gender, social disadvantage, and geographic remoteness.Design, settingRetrospective observational study; analysis of vitamin C test results undertaken at the Royal Prince Alfred Hospital, 1 January 2017 – 31 December 2021.Main outcome measuresVitamin C status (normal, serum concentration ≥ 40 μmol/L; hypovitaminosis C, 12–39 μmol/L; significant deficiency, < 12 μmol/L); associations of vitamin C status with year of testing, age, gender, socio‐economic status (Index of Relative Socio‐Economic Advantage and Disadvantage quintile), and geographic remoteness (Australian Statistical Geography Standard); rate of hypovitaminosis C or significant deficiency test results (relative to findings of normal levels; per 100 000 estimated resident population) by Statistical Area 3.ResultsOf 17 507 vitamin C tests undertaken during 2017–2021, 4573 were excluded (multiple tests for individuals); of 12 934 included results, 6654 were for women (51.5%), 9402 for people living in major cities (73.5%), and 81 for people in remote or very remote areas (0.6%). In multivariable multinomial regression analyses, significant deficiency (relative to normal test results) was more likely for men than women (adjusted odds ratio [aOR], 1.39; 95% confidence interval [CI], 1.27–1.52); the likelihood of hypovitaminosis C (IRSAD quintile 1 v 5, aOR, 1.35; 95% CI, 1.19–1.53) or significant deficiency (aOR, 2.07; 95% CI, 1.79–2.40) generally increased with postcode‐level socio‐economic disadvantage. Several of the population areas with the highest low vitamin C rates were areas of greatest disadvantage in NSW.ConclusionsThe prevalence of vitamin C deficiency among older people and people living in areas of socio‐economic disadvantage indicates that population assessment of vitamin C levels would be appropriate.

Publisher

Wiley

Subject

General Medicine

Reference29 articles.

1. Dietary Vitamin C in Human Health

2. Scurvy—Characteristic Features and Forensic Issues

3. National Health and Medical Research Council; Australian Department of Health and Ageing; New Zealand Ministry of Health.Nutrient reference values for Australia and New Zealand. Updated 13 July2017.https://www.eatforhealth.gov.au/nutrient‐reference‐values/resources(viewed May 2023).

4. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)

5. On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers

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