The predicted impact and cost‐effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome

Author:

Kang Yoon‐Jung1ORCID,Killen James1,Caruana Michael1,Simms Kate1,Taylor Natalie1,Frayling Ian M23,Snowsill Tristan4,Huxley Nicola5,Coupe Veerle MH6,Hughes Suzanne1,Freeman Victoria1,Boussioutas Alex78,Trainer Alison H9,Ward Robyn L1011,Mitchell Gillian9,Macrae Finlay A8,Canfell Karen11011

Affiliation:

1. Cancer Research DivisionCancer Council New South Wales Sydney NSW

2. Institute of Medical GeneticsUniversity Hospital of Wales Cardiff United Kingdom

3. Institute of Cancer and GeneticsCardiff University Cardiff United Kingdom

4. University of Exeter Medical School Exeter United Kingdom

5. Centre for Health Economics, Monash Business SchoolMonash University Melbourne VIC

6. Amsterdam Public Health Research InstituteVU University Medical Center Amsterdam The Netherlands

7. University of Melbourne Melbourne VIC

8. Royal Melbourne Hospital Melbourne VIC

9. Parkville Familial Cancer CentrePeter MacCallum Cancer Institute Melbourne VIC

10. University of Sydney Sydney NSW

11. University of New South Wales Sydney NSW

Funder

National Health and Medical Research Council

Cancer Council NSW

Publisher

AMPCo

Subject

General Medicine

Reference25 articles.

1. Hereditary Colorectal Cancer

2. Genetic testing for heritable mutations in the mismatch repair genes (MMR‐genes);Cancer Institute NSW;eviQ (Cancer Treatments Online)

3. Referral guidelines for colorectal cancer or polyposis risk assessment and consideration of genetic testing;Cancer Institute NSW;eviQ (Cancer Treatments Online)

4. National Institute for Health and Care Excellence.Molecular testing strategies for Lynch syndrome in people with colorectal cancer (Diagnostic guidance G27). Feb 2017.https://www.nice.org.uk/guidance/dg27(viewed July 2019).

5. Current mismatch repair deficiency tumor testing practices and capabilities: A survey of Australian pathology providers

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