Correlation Relations between Endothelial Monocyte Activating Polypeptide-ІІ and Troponin I in Patients with Comorbid Pathology

Abstract

The purpose of the study was to investigate the correlation between the levels of endothelial monocyte activating polypeptide-ІІ and troponin I in patients with acute myocardial infarction and diabetes mellitus type 2. Materials and methods. 120 patients took part in the study: 1st group – acute myocardial infarction patients with diabetes mellitus type 2 (n=70), 2nd group – patients with acute myocardial infarction (n=50). The control group included 20 practically healthy people. According to the orders of the Ministry of Health of Ukraine, the patients were diagnosed with acute myocardial infarction and diabetes mellitus type 2. All patients underwent laboratory and instrumental examinations on the first day of acute myocardial infarction. The level of endothelial monocyte activating polypeptide-ІІ (EMAP-II) was determined using the "Human Endothelial monocyte activating polypeptide-ІІ ELISA KIT" test system. Statistical processing of the research results was carried out using the "Statistica 6.0" software package. Results and discussion. The average level of endothelial monocyte activating polypeptide-ІІ on the first day of acute myocardial infarction was: in patients who were part of the 1st group – 4.54±0.331 ng/ml; 2nd – 2.74±0.21 ng/ml; in the control group – 1.1±0.037 ng/ml (р<0.05). The average level of troponin I on the first day of acute myocardial infarction was: in patients of the 1st group – 4.89±2.46 ng/ml; 2nd – 2.67±2.06 ng/ml; in the control group – 0.06±0.04 ng/ml (р˂0.00001). In the course of the correlation analysis, a direct significant correlation was found between the levels of endothelial monocyte activating polypeptide-ІІ and troponin I (r=0.700; p˂0.05). Correlation between the levels of endothelial monocyte activating polypeptide-ІІ and troponin I in patients of the 1st group was: between these indicators in patients who had a mild form of diabetes mellitus type 2 – a direct strong correlation (r=0.900; p˂0.05); moderate – a direct noticeable correlation (r=0.439; p>0.05); difficult – direct strong correlation (r=0.754; p˂0.05). Conclusion. Endothelial monocyte activating polypeptide-ІІ has a high diagnostic value in patients with acute myocardial infarction with diabetes mellitus type 2. When patients with the above-mentioned diseases were combined, the level of this indicator was significantly higher than in patients with isolated acute myocardial infarction and the control group (p<0.05). Troponin I hyperactivity was detected in patients with acute myocardial infarction, especially when combined with diabetes mellitus type 2 (p<0.00001). When determining the above-mentioned indicators in patients of the 1st group according to the forms of diabetes mellitus type 2, a directly proportional dependence with these parameters was found (р<0.05). In the course of the correlation analysis, a direct significant correlation between the levels of endothelial monocyte activating polypeptide-ІІ and troponin I was revealed (р˂0.05)