Author:
Sosnin D. Y.,Shchekotova A. P.,Pavlenina L. S.,Piniagina P. D.
Abstract
The presented case demonstrates the importance of a comprehensive analysis of all the examination data in a patient with paroxysmal nocturnal hemoglobinuria (PNH). A comparison was made of anamnesis data, the clinical picture of the disease, the results of biochemical blood analysis and hematological analyzer data with morphological assessment of cells in a stained blood smear. The interest of this case for hematologists and laboratory specialists is due to the rarity of this disease, difficulties in diagnostics, the presence of 2 types of hemolysis, features of morphological changes in peripheral blood erythrocytes, as well as analysis of the dynamics of manifestations, including against the background of targeted therapy of PNH.
Publisher
Izdatel'skii dom Spektr, LLC
Reference17 articles.
1. Lugovskaja SA, Morozova VT, Pochtar’ ME, Dolgov VV. Laboratory hematology. М.: Triada; 2006. 223 p. (In Russ).
2. Deljagin VM. Diagnosis of hemolytic anemia. Pediatrija. Prilozhenie k zhurnalu Consilium Medicum. 2008;3:82-6. (In Russ).
3. Jarzutkina EV, Slobodnjuk NA. Laboratory diagnostics of anemia. Spravochnik zavedujushhego KDL. 2020;3:25-32. (In Russ).
4. Clinical laboratory diagnostics: in 2 vol. Vol. 1 / ed. prof. VV Dolgov. M.: OOO “Labdiag”; 2017. 464 p. (In Russ).
5. Zinnatullina AR, Ishmurzin GP. Difficulties in diagnosing paroxysmal nocturnal hemoglobinuria in an urban hospital. Klinicheskaja praktika. 2022;13(1):118-22. (In Russ). DOI: 10.17816/clinpract89570