Affiliation:
1. Lecturer in Chemistry, S.K.R. Govt. Degree College, Gudur. Nellore Dist., India
2. The Hindhu College, Machilipatnam, India
Abstract
In the present report, an expeditious green synthetic approach was developed for the synthesis of α-aminophosphonates 5(a-j) in good yields through one-pot three component reaction (Kabachnik-Fields reaction) in solvent-free conditions under microwave irradiation. The newly synthesized compounds were characterized by IR, NMR (1H, 13C and 31P), mass and C, H, N analysis. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p < 0.05) anti-inflammatory activity.
Publisher
Asian Journal of Chemistry