Active Copper Catalyzed Regioselective Ring Opening of Epoxides by Heterocyclic
Amines: An Efficient Protocol for Synthesis of β-Amino Alcohols
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Published:2019-09-30
Issue:3
Volume:4
Page:194-199
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ISSN:2456-8937
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Container-title:Asian Journal of Organic & Medicinal Chemistry
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language:en
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Short-container-title:Asian J. Org. Med. Chem.
Author:
Devkate Santosh S.1,
Burungale Arvind S.1,
Pise Ashok S.1,
Jadhav Sunil D.1
Affiliation:
1. Department of Chemistry, Rayat Sikshan Sanstha’s, S.M. Joshi College Hadapsar, Pune-411028, India
Abstract
The regioselective epoxide ring opening at less substituted carbon atom of epoxide were reported by
nucleophiles like heterocyclic amines which gives well known 1,2-difunctionalized amino alcohols.
These are present in many synthetic as well as natural products. The ring opening of epoxide is achieved
by cleavage with amines in presence of copper(0) as a catalyst. It is observed that the lithium
napthalenide reduction of copper(I) produces a highly reactive form of copper(0) that acts as a catalyst
for ring opening of epoxides with an amine.
Publisher
Asian Journal of Chemistry
Reference41 articles.
1. L.S. Goodman and A. Gilman, The Pharmacological Basic of Therapeutics, Macmillan: New York, edn 6, p. 16 (1980).