Affiliation:
1. Department of Chemistry, Matushri Virbaima Mahila Science & Home Science College (Affiliated to Saurashtra University), Rajkot-360007, India
Abstract
With the aim to develop an efficient strategy to synthesize pyrimidine derivatives bearing diversely
substituted amines involves four step linear protocols started with Biginelli multi-component reaction
leading to dihydropyrimidines which passing throug multistep sequantial process containing oxidation,
chlorination and catalytically free transformation of pyrimidin-2(1H)-one to 2-(N-arylamino)pyrimidines,
were evaluated for cytotoxicity study against human cancer lines HCT-116, Hep-G2 and QG-56. Compound
4j exhibit significant anticancer activity showed against: human hepato carcinoma (Hep-G2) and human
colon carcinoma (HCT-116) serve as a excellent lead molecule for the generation of various promising
targets.
Publisher
Asian Journal of Chemistry
Reference20 articles.
1. Pyrimidine as Constituent of Natural Biologically Active Compounds
2. D.H. Drewry, E. Brian, K.B. Goodman, V.S. Darren Green, D.K. Jung, D. Lee, R.A. Stavenger and S.N. Wad, Indazolo-tetrahydropyrimidine-carboxamide Derivative Kinase Inhibitors, WO2004/112719 (2004).
3. J.M. Nuss, S.D. Harrison, D.B. Ring, R.S. Boyce, S.P. Brown, D.A. Goff, K.W. Johnson, K.B. Pfister, S. Ramurthy and P.A. Renhowe, Inhibitors of Glycogen Synthase Kinase 3, Google Patents: 2006.
4. Synthesis of New N-Arylpyrimidin-2-amine Derivatives Using a Palladium Catalyst
5. Synthesis and Biological Activity of Methanesulfonamide Pyrimidine- and N-Methanesulfonyl Pyrrole-Substituted 3,5-Dihydroxy-6-heptenoates, a Novel Series of HMG-CoA Reductase Inhibitors