Affiliation:
1. Department of Chemistry, Institute of Science, Nagpur-440001, India
2. Department of Chemistry, Government Science College, Gadchiroli-442605, India
Abstract
An expeditious synthesis of series of novel 1,3,5-thiadiazine (5a-f) and (6a-f) derivatives have been
described. These compounds were synthesized by reaction of 1-(N-((6-methyl-2-(p-tolyloxy)quinoline-
3-yl)methylene)carbamimidoyl)-3-arylthiourea (3a-b) derivatives with N-aryl isocyanodichloride (4a-c)
in chloroform followed by basification with dilute NH4OH to give the target compounds 5a-f; which
were acetylated further to afford six novel 1,3,5-thiadiazin-3-(6H)-yl)ethanone (6a-f) derivatives. Synthesis
of intermediate compounds 3a-b was obtained by reacting 6-methyl-2-(p-tolyloxy)quinoline-3-
carbaldehyde (2a) and 1-carbamimidoyl-3-aryllthiourea (1a-b) in chloroform. Structures of compounds
5a-f and 6a-f were established by FTIR, 1H & 13C NMR, mass spectra and further supported by elemental
analysis. All synthesized compounds were investigated for their in vitro antimicrobial screening against
a panel of pathogenic microorganism comprising S. aureus as Gram positive while E. coli, P. vulgaris, S.
typhi as Gram-negative bacterial strains.
Publisher
Asian Journal of Chemistry
Reference31 articles.
1. New triazole and triazolothiadiazine derivatives as possible antimicrobial agents
2. Synthesis of Novel Series of Various Substituted1-(5-(2-p-tolyloxyquinolin-3-yl)-2-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanone and its Antibacterial Activity
3. E. Saglam, S. Sarac, E. Kilic, M. Ozalp and M. Ertan, Synthesis and Antimicrobial Activity of Some 3,5-Disubstituted-tetrahydro-2H-1,3,5-thiadiazine2-thione Derivatives, Turk. J. Pharm. Sci., 8, 159 (2011).
4. Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties
5. Synthesis and in vitro antimicrobial activity of some newer quinazolinone–sulfonamide linked hybrid heterocyclic entities derived from glycine