Synthesis, Characterization and Biological Evaluation of Some 2-[1-(1,3-Diphenyl-1HPyrazol-4-yl)-meth-(E)-ylidene]indan-1-one Derivatives as Antibacterial Agents

Abstract

A new series of 2-[1-(1,3-diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-indan-1-one derivatives (5a-l) have been synthesized through through the Knoevenagel condensation of pyrazole carbaldehydes with differently substituted 1-indanone derivatives in the presence of base. A high yielding and solvent-free method was developed for the synthesis of hydrazones from acetophenones under microwave irradiation in a very short reaction time. Structures of the newly synthesized compounds were affirmed by IR, 1H & 13C NMR and mass spectroscopic analysis. The confirmed structures were screened for their antibacterial potency against S. aureus and E. coli bacterial strains. Among the series, compounds 5b, 5c and 5f were evoked as potent antibacterial agents