Catalyst and Solvent Free Synthesis and Biological Activities of Imidazo[1,2-a]pyridine

Abstract

A series of imidazo[1,2-a]pyridines were synthesized by the reaction of α-chloroacetophenone and 2- aminopyridine under catalyst and solvent free condition. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral data. These imidazo[1,2-a]pyridines were screened for antiinflammatory activity by carrageenan induced rat hind paw edema model. Good anti-inflammatory activity was shown by few compounds. The antibacterial activity was studied against two Grampositive bacteria S. aureus and B. subtilis, two Gram-negative bacteria E. coli and S. typhi and antifungal activity against P. chrysogenum, F. moneliforme, A. flavus and A. niger. All the synthesized compounds were desplayed good antimicrobial and antifungal activities. Some of the compounds were shown higher antibacterial activity than reference drug penicillin.