Synthesis, Characterization & Antimicrobial Evaluation of New bis(5-Biphenyl-3-alkoxyphenyl-4,5-dihydro-1H-pyrazole-N-carbothioamide) Derivatives-Reference-Cited by-同舟云学术

Synthesis, Characterization & Antimicrobial Evaluation of New bis(5-Biphenyl-3-alkoxyphenyl-4,5-dihydro-1H-pyrazole-N-carbothioamide) Derivatives

Published:2020 Issue:1 Volume:5 Page:77-83
ISSN:2456-8937
Container-title:Asian Journal of Organic & Medicinal Chemistry
language:en
Short-container-title:Asian J. Org. Med. Chem.

Author:

Nisa Shehneela¹,Yusuf Mohamad¹

Affiliation:

1. Department of Chemistry, Punjabi University, Patiala-147002, India

Abstract

In this study, a series of new symmetrical N-carbothioamide substituted bispyrazolines (2a-f) had been systematically synthesized by using ring closure reactions of bischalcones (1a-f) with thiosemicarbazide under the alkaline-alcoholic conditions. The structures of bisheterocyclic products have been fully characterized on the basis of their IR, 1H & 13C NMR and ESI-MS spectral strategies. All the prepared compounds were also evaluated for their in vitro antimicrobial assay with the help of serial tube dilution procedure against the selected numbers of microbes (seven bacterial and five fungal strains). The most of the synthesized bisheterocycles exhibited noticeable antimicrobial potencies against the tested strains

Publisher

Asian Journal of Chemistry

Reference42 articles.

1. 10.1002/(SICI)1521-3897(199902)341:2<99::AIDPRAC99>3.0.CO;2-Z

2. R. Dua, S. Shrivastava, S.K. Sonwane and S.K. Srivastava, Pharmacological Significance of Synthetic Heterocycles Scaffold: A Review, Adv. Biol. Res. (Faisalabad), 5, 120 (2011).

3. Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics

4. L.D. Quin and J.A. Tyrell, Fundamentals of Heterocyclic Chemistry: Importance in Nature & in the Synthesis of Pharmaceuticals, John Wiley & Sons (2010).