An Efficient Synthesis of Novel Triazolo-pyrimidine Derivatives using Copper Catalyzed Click Chemistry (CuAAC) Approach

Abstract

To synthesize new chemical entities, we have a focus on the aryl or heteroaryl compounds. The current work also relates to the synthesis of pharmaceutical and medicinally active compositions containing these types of compounds and their vast application of treating a wide class of diseases i.e. anticancer, antibacterial, antifungal, antimalarial via administering substituted aryl or heteroaryl compounds. In this work, an efficient synthetic route is developed to explore a wide variety of 1H-1,2,3-triazol-1-yl-N- (4-phenylpyrimidin-2-yl)acetamide derivatives and convergent access a diverse array of triazolopyrimidine analogs via click chemistry approach. The structures elucidation was completed by using 1H & 13C NMR, FT-IR, mass spectroscopy, elemental analysis. The developed morpholino-pyrimidine derivatives were further utilized of a diverse range of their chemotherapeutic value.