Synthesis, Characterization, Antimalarial and Anticancer Activities of Few New Amino Analogues of 1,4-Naphthoquinone-Reference-Cited by-同舟云学术

Synthesis, Characterization, Antimalarial and Anticancer Activities of Few New Amino Analogues of 1,4-Naphthoquinone

Published:2022 Issue:1 Volume:7 Page:123-130
ISSN:2456-8937
Container-title:Asian Journal of Organic & Medicinal Chemistry
language:en
Short-container-title:Asian J. Org. Med. Chem.

Author:

Sanjay S.S.¹,Shashiprabha ²,Shridhara K.³,Nagarajan K.⁴,Sivaramakrishnan H.⁵,Arun B.⁶

Affiliation:

1. 1Department of Chemistry, Sri Dharmasthala Manjunatheshwara Institute of Technology (Affiliated to Visvesvaraya Technological University, Belagavi), Ujire-574240, India 2Alkem Laboratories Limited, Research & Development Centre, Peenya Industrial Area, Bangalore-560058, India

2. 2Alkem Laboratories Limited, Research & Development Centre, Peenya Industrial Area, Bangalore-560058, India 3PG Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India

3. 2Alkem Laboratories Limited, Research & Development Centre, Peenya Industrial Area, Bangalore-560058, India 4Technical Coordinator, ArkGen Pharma Private Limited, Peenya Industrial Area, Bangalore-560058, India

4. 2Alkem Laboratories Limited, Research & Development Centre, Peenya Industrial Area, Bangalore-560058, India 5#1st Floor, House No. 007, Serene Urbana, Ozone Urbana, Southe Gowdanahalli, Bangalore-562110, India

5. Piramal Life Sciences, 1-Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai-400063, India

6. 7Chief Innovation Officer, Omni Active Health Technologies Limited, Phoenix House, T-8, A-Wing, 462-Senapati Bapat Marg, Lower Parel, Mumbai-400013, India

Abstract

Present study involves the synthesis, characterization, antimalarial and anticancer activities of some novel substituted amino analogues of 1,4-naphthoquinone. The chloro group present in the key starting materials like 2,3-dichloro-1,4-naphthoquinone (1) and 2-chloro-3-[trans-4-(4-chlorophenyl)- cyclohexyl]-1,4-naphthoquinone (2) was replaced by substituted amines. These analogues were isolated, purified and screened for antimalarial and anticancer activities. A few of the novel compounds were found to possess substantial biological activity and are reasonably potent.

Publisher

Asian Journal of Chemistry

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