Affiliation:
1. Department of Chemistry, Saurashtra University, Rajkot-360005, India
Abstract
In present study, an efficient and greener protocol is developed for the synthesis of 5-(4-(substituted
[1,1′-biphenyl]-4-yl-methoxy)benzyl)-thiazolidine-2,4-diones by using microwave irradiations. Here,
a one-pot reaction between 5-(4-((4-bromobenzyl)oxy)benzyl)thiazolidine-2,4-dione, substituted aryl
boronic acid and K2CO3 in the presence of toluene:water:ethanol solvents under conventional heating
methods and microwave irradiation methods is reported. All the final compounds were characterized by
FT-IR, 1H NMR, 13C NMR and mass spectroscopic analysis. The antimicrobial evaluation studies
show moderate activities against used microbes.
Publisher
Asian Journal of Chemistry
Reference19 articles.
1. Synthesis of Biologically Active Molecules through Multicomponent Reactions
2. Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2,4‐dichloro)benzylidene]thiazolidine‐2,4‐dione derivatives as VEGFR‐2 inhibitors
3. An overview on medicinal perspective of thiazolidine-2,4-dione: A remarkable scaffold in the treatment of type 2 diabetes
4. Thiazolidine-2,4-diones: Progress towards multifarious applications
5. S. Mohanty, G.S. Reddy and A.C. Karmakar, Synthesis of New 5-Substituted–aminomethylene-thiazolidine-2,4-dione Derivatives as Potential Antibacterial Agents, J. Applicable Chem., 3, 82 (2014).