Synthesis and Antimicrobial Activity of 1,2,3-Triazole Linked Benzo[d]oxazole-2-thiol/ oxazolo[4,5-b]pyridine-2-thiol Derivatives-Reference-Cited by-同舟云学术

Synthesis and Antimicrobial Activity of 1,2,3-Triazole Linked Benzo[d]oxazole-2-thiol/ oxazolo[4,5-b]pyridine-2-thiol Derivatives

Published:2021 Issue:1 Volume:6 Page:7-12
ISSN:2456-8937
Container-title:Asian Journal of Organic & Medicinal Chemistry
language:en
Short-container-title:Asian J. Org. Med. Chem.

Author:

Gour Pankaj¹^ORCID,Deshmukh Lata²,Dadmal Tulshiram³^ORCID,Ramteke Archana¹

Affiliation:

1. Department of Chemistry, K.D.K. College of Engineering, Nandanvan, Nagpur-440009, India

2. Department of Chemistry, Hislop College, Civil Line, Nagpur- 440001, India

3. Department of Chemistry, Government of Maharashtra's Ismail Yusuf College, Jogeshwari (E), Mumbai-400060, India

Abstract

A new series of 1,2,3-triazole linked mercaptobenzoxazole/oxazolo- [4,5-b] pyridine-2-thiol derivatives (6a-j) were synthesized starting from 2-aminophenol/2-aminopyridin-3-ol in three steps via cyclization, alkylation followed by reaction with various aromatic azides using click chemistry approach. All the synthesized compounds were evaluated for their antimicrobial activity viz. E. coli, P. aeruginosa, S. aureus and S. pyogenus and three pathogenic fungi viz. C. albicans, A. niger and A. clavatus and promising compounds were identified.

Publisher

Asian Journal of Chemistry

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