Synthesis, Characterization and Hypoglycemic Efficacy of Isonicotinohydrazide Phenoxy Quinolines: An in silico Studies

Abstract

Prevention of α-amylase and β-glucosidase to reduce the postprandial blood sugar levels and delays dextrose absorption, the natural inhibitors provide an interesting approach to manage hyperglycemia with type 2 diabetes. The α-amylase and β-glucosidase are important therapeutic targets for type II diabetes. The isonicotinohydrazide phenoxy quinolines (5a-l) were synthesized and characterized by mass, 1H & 13C NMR. The characterized compounds are investigated for their in silico anti-hyperglycemic efficacy and the compounds shown effective to moderate inhibition against α-amylase and β-glucosidase enzymes. A molecular modelling study was performed for all the synthesized compounds to find the binding interaction of 5a-l with the α-amylase and β-glucosidase.