Imidazole-2-carboxaldehyde Chitosan Thiosemicarbazones and their Copper(II) Complexes: Synthesis, Characterization and Antitumorigenic Activity against Madin-Darby Canine Kidney Cell Line-Reference-Cited by-同舟云学术

Imidazole-2-carboxaldehyde Chitosan Thiosemicarbazones and their Copper(II) Complexes: Synthesis, Characterization and Antitumorigenic Activity against Madin-Darby Canine Kidney Cell Line

Published:2021 Issue:5 Volume:33 Page:969-976
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Adhikari Hari Sharan¹^ORCID,Garai Aditya²^ORCID,Khanal Chetana³^ORCID,Adhikari Rameshwar⁴^ORCID,Yadav Paras Nath⁵^ORCID

Affiliation:

1. Institute of Engineering, Pashchimanchal Campus, Department of Applied Sciences, Tribhuvan University, Pokhara, Nepal

2. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012, India

3. Central Department of Biotechnology, Tribhuvan University, Kathmandu, Nepal

4. 4Research Centre for Applied Science and Technology (RECAST), Tribhuvan University, Kathmandu, Nepal 5Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal

5. Central Department of Chemistry, Tribhuvan University, Kathmandu, Nepal

Abstract

Chitosan oligosaccharide and high molecular weight crab shell chitosan were functionalized as imidazole-2-carboxaldehyde chitosan thiosemicarbazones and their copper(II) complexes were synthesized. The synthesized compounds were characterized by FT-IR, 13C NMR, EPR spectroscopy, powder X-ray diffraction (PXRD) analysis, elemental analysis and magnetic susceptibility measurements. The low molecular weight chitosan thiosemicarbazones showed higher in vitro inhibitory activity as studied by MTT assay against the tumorigenic epithelial Madin-Darby Canine Kidney (MDCK) cell line than the corresponding high molecular weight chitosan derivative. The antitumorigenic enhancement upon the complex formation was revealed by the better inhibitory activity of copper(II) chitosan thiosemicarbazone chelates.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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