Affiliation:
1. Department of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Hyderabad-502329, India
Abstract
In present work, the isolation, synthesis and characterization of the identified triol impurity present in
tafluprost is described. This investigation helps to avoid formation of impurity by control the reaction
and its leads to improving high yields of tafluprost. The source of impurity was identified, due to
over-reduction of lactone with diisobutyl aluminum hydride (DIBAL-H).
Publisher
Asian Journal of Chemistry
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