Synthesis of Multi-Substituted 4,5-Dihydrofurans: Microwave Assisted Reaction of β-Ketonitriles, Aldehydes and Pyridinium Phenacyl Salts via [1+1+3] Knoevenagel-Michael-Oxa-Michael Cyclization Triple Cascade Sequence-Reference-Cited by-同舟云学术

Synthesis of Multi-Substituted 4,5-Dihydrofurans: Microwave Assisted Reaction of β-Ketonitriles, Aldehydes and Pyridinium Phenacyl Salts via [1+1+3] Knoevenagel-Michael-Oxa-Michael Cyclization Triple Cascade Sequence

Published:2022-12-27 Issue:1 Volume:35 Page:224-232
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Chimaladenne Venkateswarlu¹^ORCID,Surapureddi Sri Rama Krishna²^ORCID,Valluru Krishna Reddy³^ORCID,Kampli Anil³^ORCID,Brahman Pradeep Kumar²^ORCID,Gudise Veera Babu³^ORCID,Vijaya Laxmi Somarapu⁴^ORCID

Affiliation:

1. 1Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India 2Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, India

2. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India

3. Chemistry Services, Aragen Life Sciences, Survey Nos: 125 (part) & 126, IDA Mallapur, Hyderabad-500076, India

4. 1Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Tadepalli, Guntur-522502, India 3Department of Chemistry, Palamuru University, Mahabubnagar-509001, India

Abstract

A microwave assisted protocol for the development of fully substituted dihydrofurans has been explained as a three component triple cascade reaction between pyridinium ylide, phenacyl nitriles and aldehydes. This [1+1+3] annulation protocol produced the dihydrofurans having two stereocentres. A total of 14 molecules have been synthesized with high chemical yields.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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