Synthetic Approach, Structural Performance and in vitro Antibacterial Activity: Nitrogen and Oxygen Donor Atoms containing Bidentate Schiff Base Ligand and its Mononuclear Complexation with Co(II) and Cu(II) Metal Ions

Abstract

A synthetic approach has been designed and followed for the synthesis of new bidentate Schiff base ligand 2-acetylthiophenenicotinic hydrazone (L) (which possessed nitrogen and oxygen donor atoms) and its Co(II) and Cu(II) mononuclear complexes. All the compounds were examined IR, 1H NMR, mass, EPR, conductivity, elemental analysis, etc. Octahedral geometry has been assigned to all synthesized compounds on the basis of magnetic, IR and electronic spectral analysis. In vitro activity i.e. antibacterial (E. coli and P. aeruginosa) and antifungal (A. niger, M. phasolina and P. glomerata) had been examined for these compounds following well diffusion and poisoned food methods, respectively. During the performance of antifungal activity, antifungal agent was incorporated into the molten agar at various concentrations and mixed well. After performance of in vitro activity, it has been resulted out that metal(II) complexes exhibited remarkable activity than free ligand but less active compared to the standard drugs..