Affiliation:
1. Department of Applied Chemistry, Karunya Institute of Technology and Sciences, Coimbatore-641114, India
2. Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore-641114, India
Abstract
The inorganic cobaloximes of type [Co(Cl)(dmgH)2B]; where dmgH = dimethyl glyoxime and B =
neutral bases: glycine, ethyl amine, 2-aminopyridine, 4-aminopyridine, 2,6-diaminopyridine, aniline
and 1-napthylamine have been synthesized. The synthesized cobaloximes were characterized by IR,
UV-visible, 1H NMR and 13C NMR spectroscopic techniques. The cobaloxime complexes were screened
for their antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and
Acinetobacter baumannii by the zone of inhibition test, biofilm eradication on biomaterial using catheter
and modified Congo red agar method. It has been found that the cobaloxime complexes exhibit inhibition
against both gram positive and gram negative bacteria and the cobaloximes showed better inhibition
towards Gram-negative bacteria compared to Gram-positive bacteria.
Publisher
Asian Journal of Chemistry