A Concise and Efficient Synthesis of an Impurity, N-Desmethyl Alcaftadine from Alcaftadine: An H1 Antagonist-Reference-Cited by-同舟云学术

A Concise and Efficient Synthesis of an Impurity, N-Desmethyl Alcaftadine from Alcaftadine: An H1 Antagonist

Published:2019-08-30 Issue:10 Volume:31 Page:2257-2260
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Sravya G.¹,Zyryanov Grigory V.²,Ramaseshaiah K.³,Reddy G. Malli Karjuna¹,Reddy C. Suresh⁴,Reddy N. Bakthavatchala¹

Affiliation:

1. Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russia

2. I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, Yekaterinburg 620219, Russia

3. Rajeev Gandhi Memorial College of Engineering and Technology (Autonomous), Nandyal-518501, India

4. Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India

Abstract

Herein, a simple approach for the synthesis of N-desmethyl alcaftadine, an H1 histamine antagonist in solid state and its structure is presented. The reactions were performed under mild and metal free conditions at reflux temperature within a range of 65-70 ºC and the desired product N-desmethyl alcaftadine was obtained in high purity with good yield (96.42 %). It was detected by ultra-high-performance liquid chromatography (UHPLC).

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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