Emerging Potential of Metallodrugs to Target Coronavirus: Efficacy, Toxicity and their Mechanism of Action

Abstract

On eleventh March 2020, the contagion of the novel COVID-19 was announced by the WHO. Right now, there are no new enlisted medications that can viably cure the COVID-19 contagion. Some recently utilized drugs and combinations with their harmfulness profiles have been contemplated. The frequently announced poisonous impacts of these medicines, for example, hepatotoxicity, retinal harm, nephrotoxicity and cardiotoxicity. One of the most broadly examined drugs is favipiravir. The surface collaboration of favipiravir with organometallic composites came about by doping of transition metals of first row of the periodic table was analyzed to choose the most reasonable metallofullerenes for COVID-19 treatment. Some acknowledged pharmacophore edifices of bioactive constituents can be valuable in the explanation of against SARS-CoV-2 particulars. The advantage of utilizing arrangements encompassing phytochemicals is their sky-scraping wellbeing for ill persons and no negative reaction. Iron oxide nanoparticles (IONPs) were recently affirmed by the USFDA for anaemia therapy and variations have additionally exhibited its effectiveness against viruses in vitro for COVID-19. The adequacy of the Zn2+ salt enhancement could likewise be improved with Nigella sativa as its major bioactive segment would fill in as ionophore to permit Zn2+ to enter pneumocytes-the objective cell for the coronavirus (COVID-19). This review article depicts the utilization of medications, their usefulness and their harmful impacts for COVID-19 patients.