Design, Synthesis and Pharmacological Assay of Sulfadiazine based Azo-Metal Complexes

Abstract

This study reported the biologically active Cu(II), Co(II) and Ni(II) complexes of the novel azo dye ligand pyrimidin-2-yl-4-[(E)-(2,4,6-trioxohexahydropyrimidin-5-yl)diazenyl]benzenesulfonamide. The structures of synthesized metal complexes were established on spectroscopic and physico-chemical techniques. From the spectral studies, it confirms that the azo ligand coordinates to the metal center through a bidendate manner via barbutaric acid -OH, azo-N as a donor site. The thermal studies reveals that all the complexes exhibits good thermally stability and also the presence of water molecule for Co(II) and Ni(II) complexes. The prepared metal chelates have been examined for their antibacterial activity against Staphylococcus aureus, Xanthomonas campestris, Klebsiella pneumonia and E. coli by using agar well diffusion method. The data revealed the ability of the complexes to inhibit the growth of some microorganisms, among all the compounds Co(II) complex showed the highest activity. The antifungal activity of the compounds were tested against two strains, whereas Ni(II) complex showed the highest activity against fungal strains. Lastly, the probable binding sites of metal complexes with receptor RpsA were studied by molecular docking studies.