Identification, Isolation and Origin of Potential Dimer Impurities of Dichlorphenamide: A Carbonic Anhydrase Inhibitor Drug (Antiglaucoma)-Reference-Cited by-同舟云学术

Identification, Isolation and Origin of Potential Dimer Impurities of Dichlorphenamide: A Carbonic Anhydrase Inhibitor Drug (Antiglaucoma)

Published:2021 Issue:6 Volume:33 Page:1249-1252
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Reddy T. Purendar¹^ORCID,Dussa Nageshwar²,Mamidi Srinivas²,Panasa Mahesh²,Chavakula Ramadas²,Padma M.³

Affiliation:

1. 1Chemical Research Department, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran Village, Kandi Mandal, Sangareddy District-502329, India 2Department of Engineering Chemistry, A.U. College of Engineering (A), Andhra University, Visakhapatnam-530003, India

2. Chemical Research Department, APL Research Centre-II, Aurobindo Pharma Ltd., Survey No. 71 & 72, Indrakaran Village, Kandi Mandal, Sangareddy District-502329, India

3. Department of Engineering Chemistry, A.U. College of Engineering (A), Andhra University, Visakhapatnam-530003, India

Abstract

Present work describes the identification, isolation and characterization of two new process related dimeric impurities of dichlorphenamide (1). During the synthesis of dichlorphenamide, the formation of two new dimeric impurities namely 2,3-dichloro-5-(3,4-dichloro-5-sulfamoyl-phenyl)sulfonylbenzenesulfonamide (2) (1,1Œ-dichlorphenamide dimer) and 2,3-dichloro-5-(2,3-dichloro-5-sulfamoylphenyl) sulfonyl-benzenesulfonamide (3) (1,3Œ-dichlorphenamide dimer) was observed. In addition, origin and the strategies adapted to control these potential dimer impurities were also described. These impurities have a substantial impact on the quality of the drug substance as well as drug product.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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