Microwave Assisted Synthesis of Quinoline Fused Benzodiazepines as Anxiolytic and Antimicrobial Agents-Reference-Cited by-同舟云学术

Microwave Assisted Synthesis of Quinoline Fused Benzodiazepines as Anxiolytic and Antimicrobial Agents

Published:2021 Issue:5 Volume:33 Page:1107-1114
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Marganakop S.B.¹,Kamble R.R.¹^ORCID,Nesaragi A.R.²^ORCID,Bayannavar P.K.²^ORCID,Joshi S.D.²,Kattimani P.P.²,Sudha B.S.³^ORCID

Affiliation:

1. Department of Studies in Chemistry, Karnatak University, Dharwad-580003, India

2. Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S.E.T.’s College of Pharmacy, Sangolli Rayanna Nagar, Dharwad-580002, India

3. Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore-570005, India

Abstract

In the present study, an efficient, facile and green protocol for synthesis of quinoline fused 1,4-benzodiazepine (4a-j) by microwave irradiated condensation of 6/7/8-substituted 3-bromomethyl- 2-chloro-quinoline (3a-j) obtained from 2-chloro 6/7/8-substituted quinoline-3-carbaldehyde (1a-j) with 1, 2-phenylenediamine was developed. Surflex docking studies with K+ channel is one of the physiological targets and inhibition, which plays a role in the pathophysiology of depression revealed that all these compounds show consensus score in the range 2.71-3.68 indicating the summary of all forces of interaction. Further, compounds 4d, 4g and 4i exhibited potent antibacterial activity

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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