Synthesis, Characterization, Antimicrobial and Cytotoxic Investigations of Some Transition Metal(II) Complexes with Tridentate Schiff Base Derived from Pyrrolopyrimidine

Abstract

A Schiff base pyrrolopyrimidine-hydrazide-m-chlorobenzaldehyde (HPPHmCB) was synthesized via condensation reaction between a pyrrolopyrimidinehydrazide and 3-chlorobenzaldehyde and its transition metal(II) complexes complexes followed by the characterization and electrochemical analysis. The magnetic susceptibility, electrolytic conductivity, elemental analysis, FT-IR, electronic absorption, ESR and PMR spectra were employed to elucidate the structural properties. The Schiff base HPPHmCB ligand acts as a tridentate N,N,N donor and produces complexes of type [M(PPHmCB)2], which exhibit a square planar geometry for Pd(II) complex, tetrahedral for Hg(II), Cd(II) and Zn(II) complexes and octahedral geometry for Mn(II), Cu(II), Fe(II), Co(II) and Ni(II) complexes. The minimum inhibitory concentration (MIC) approach was used to screen the in vitro antibacterial and antifungal activities of synthesized Schiff base HPPHmCB ligand and its metal(II) complexes. The results showed that the significant microbial activities by both ligand and its transition metal(II) complexes. Moreover, in vitro cytotoxicity properties of Schiff base HPPHmCB ligand and its metal(II) complexes were also investigated against Artemia salina using the brine shrimp bioassay.