Surface Functionalization of MnFe2O4 Nanoparticles with Ethylenediamine for Hyperthermia Application

Abstract

Biocompatible magnetic nanoparticles with enhanced heating proficiency are required for magnetic hyperthermia in order to use it efficiently in cancer treatment. In this paper, ethylenediamine functionalized monodispersed manganese iron oxide (MnFe2O4) nanoparticles were synthesized by using polyol method and functionalized nanoparticles were characterized by using X-ray diffraction, scanning electron microscope, transmission electron microscopy, vibrating sample magnetometry, fourier transform infrared spectroscopy and thermogravimetric analysis techniques for structural, morphological and magnetic analysis. Hyperthermia characteristics of functionalized MnFe2O4 nanoparticles were studied at 167.6, 251.4 and 335.2 Oe to assess the feasibility magnetic hyperthermia anticancer therapy. Outcome revealed that nanoparticles the self-heating temperature rise up to 48.76 to 56.34 °C at 5 and 10 mg mL-1 concentrations in water respectively. Specific absorption rate 94.65 W g-1 was observed at 5 mg mL-1 concentration. Biocompatibility study of functionalized nanoparticles has divulged almost no toxicity for nanoparticles.