Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives-Reference-Cited by-同舟云学术

Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives

Published:2020 Issue:5 Volume:32 Page:1101-1108
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Sharma Vijay Kumar¹,Barde Anup²,Rattan Sunita³

Affiliation:

1. Amity Institute of Applied Sciences, Amity University Uttar Pradesh, Noida-201313, India 2Integral Bio Sciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II Noida-201306, India

2. Integral Bio Sciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II Noida-201306, India

3. Amity Institute of Applied Sciences, Amity University Uttar Pradesh, Noida-201313, India

Abstract

Novel thiazolidine-2,4-dione (TZD) based pyrimidine derivatives have been synthesized by Knoevenagel condensation reaction between thiazolidine-2,4-dione and amino pyrimidinyl aliphatic aldehydes followed by heterogeneous metal reduction. Synthetic strategy involved nucleophillic substitution of hydroxyl protected six membered aliphatic chain on 4,6-dichloropyrimidine followed by Suzuki coupling. This approach is regioselective, efficient and versatile for synthesis of such analogs

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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