Structure Elucidation of New Flavone and Antioxidant, Anti-Inflammatory Activities from Leaves of Vitex negundo Linn.

Abstract

A medicinally active chemical investigation on the leaves of Vitex negundo induce the confinement and identification of flavones apigenin (1), kaempferol (2) and one new flavone 5,7,4′-trihydroxy-3,3′,6,8-tetramethoxy flavone (3) and one known and rare flavone 5,7,4′-trihydroxy-6,3′,5′-trimethoxyflavone (4). These compounds composition were well-established on account of chromatography and spectroscopic sign and correlation with literature data. Antioxidant and carrageenan-induced paw edema in male albino rats were determined. Compounds 1 and 2 exhibited the most potent antioxidant effect at a dose of 200 mg/kg. Compound 1 produced noticeable anti-inflammatory effects (2.66 ± 0.08 at 3 h of injection) lightly off that of other compounds.