In vitro Antitubercular Screening and in silico Study of Germacradienolide from Blainvillea latifolia-Reference-Cited by-同舟云学术

In vitro Antitubercular Screening and in silico Study of Germacradienolide from Blainvillea latifolia

Published:2021 Issue:12 Volume:33 Page:3129-3133
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Honmore Varsha S.¹^ORCID,Kalyankar Vidya K.¹,Natu Arun D.¹,Khedkar Vijay M.²,Sarkar Dhiman³,Rojatkar Supada R.⁴

Affiliation:

1. Post Graduate and Research Center, Department of Chemistry, MES Abasaheb Garware College, Pune-411004, India

2. Department of Pharmaceutical Chemistry, School of Pharmacy, Vishwakarma University, Pune-411048, India

3. Combichem-Bioresource Center, Organic Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune- 411008, India

4. R&D Centre in Pharmaceutical Sciences and Applied Chemistry, Poona College of Pharmacy Campus, Bharati Vidyapeeth Deemed University, Erandwane, Pune-411038, India

Abstract

Bioassay-guided isolation from acetone extract of Blainvillea latifolia yielded one compound. The acetone extract, fractions and the compound 1 were investigated for antitubercular activity against Mycobacterium tuberculosis H37Ra. Compound 1 showed the activity with IC50 and MIC values at 8.9 and >100 μg/mL. However, the acetone extract of Blainvillea latifolia was inactive against two Gram negative (E. coli, P. flurescence) and two Gram-positive (S. aureus, B. subtilis) bacterial strains. Hence, it was concluded that the extract and the compound 1 are specifically active against MTB and not against bacterial strains. Molecular docking study was performed against crucial mycobacterial target MtInhA to gain an insight into the binding mode and the thermodynamic interactions governing the binding affinity of this molecule.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

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