Abstract
A simple and efficient method has been employed for synthesis of a novel series of biologically active α-aminophosphonates (4a-j) by reacting 1H-benzo[d]imidazole-2-carbaldehyde (1) and various aromatic amines (2a-j) and diethyl/dimethyl phosphite (3) by Kabachnik-Field's reaction in the presence of efficient heterogeneous K2CO3/Al2O3 catalyst under solvent-free conditions at 140 ºC. Structures of all the compounds were confirmed by 1H, 13C and 31P NMR and LC-MS. In addition to this antioxidant activity were also evaluated.
Publisher
Asian Journal of Chemistry
Cited by
7 articles.
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1. Recent Advances in the Synthesis of Dialkyl (Aryl) α-(Aryl/Heterocyclic/Heteroaryl- α-(Aryl/Heteroarylamino)Phosphonates;Current Organic Chemistry;2023-09
2. Metal Oxides as Catalysts/Supports in Solvent‐Free Organic Reactions;Solvent‐Free Methods in Nanocatalysis;2023-01-13
3. Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik−Fields Reaction;Materials;2022-05-27
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5. Synthesis and in vitro antimicrobial, antioxidant, and antiproliferative activities of some new pyrano[2,3-c]pyrazoles containing 1,2-azaphospholes, 1,3,2-diazaphosphinines and phosphonate moieties;Synthetic Communications;2021-06-18