Synthesis, Molecular Docking and Radical Scavenging Activity of 1,2,4,5-Tetrasubstituted Imidazole Derivatives-Reference-Cited by-同舟云学术

Synthesis, Molecular Docking and Radical Scavenging Activity of 1,2,4,5-Tetrasubstituted Imidazole Derivatives

Published:2019-09-28 Issue:11 Volume:31 Page:2448-2452
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Bhadrachar Somashekara¹,Vijayakumar Giriyapura R.¹,Mahadevan Kittappa M.²,Basavaraja Thippeswamy³

Affiliation:

1. Department of Chemistry, University College of Science, Tumkur University, Tumkur-572103, India

2. Department of Chemistry, Kuvempu University, P.G. Centre, Kadur-577548, India

3. Department of Chemistry, Government Science College, Chithradurga-577501, India

Abstract

A series of 1,2,4,5-tetrasubstituted imidazoles (2a-g) were synthesized using 1,2-diketone, 1-naphthaldehyde, substituted aromatic amine and ammonium acetate in the presence of ceric ammonium nitrate as a catalyst. The synthesized compounds were characterized by FT-IR, 1H NMR, Mass spectra and explored for their antioxidant activity by DPPH free radical scavenging assay method. Among the synthesized compounds 2a, 2e and 2f exhibit good antioxidant activities. Molecular docking study was also been performed to know the possible interactions between the synthesized compound and antioxidant receptor 3MNG.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

Reference30 articles.

1. Synthesis and Activity of Novel Indole Linked Triazole Derivatives as Antifungal Agents

2. SYNTHESIS OF TETRASUBSTITUTD IMIDAZOLES CONTAINING INDOLE AND THEIR ANTIUREASE AND ANTIOXIDANT ACTIVITIES

3. Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives

4. Synthesis and analgesic activity of some 1-benzyl-2-substituted-4,5-diphenyl-1H-imidazole derivatives

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