Isolation, Semi-Synthesis and Antifeedant Activity of Constituents from Derris scandens Benth.

Abstract

This work describes the semi-synthesis of derivatives from derris isoflavone-A (1), scandenin (2) and 6,8-diprenyl-4′,5,7-trihydroxy isoflavone (3) which are major constituents isolated from chloroform extract of Derris scandens Benth. All the semi-synthesized derivatives (4-11) were characterized by NMR and mass spectroscopic techniques. All these derivatives are evaluated for their antifeedant activity in castor semilooper and tobacco caterpillar using a no-choice laboratory bioassay. The results demonstrated that scandenin (2), compounds 5, 7 and 10 have shown potent insecticidal activity.