Affiliation:
1. Department of Chemistry, A.V.V.M. Sri Pushpam College (Autonomous) (Affiliated to Bharathidasan University, Tiruchirapalli), Poondi, Thanjavur-613503, India
Abstract
A straightforward synthetic procedure for thioamides has been developed at 100 ºC using pyrazole
aldehyde, a secondary amine, precipitated elemental sulphur and DMSO as solvent. The
Willgerodt-Kindler reaction was successfully carried out by increasing the mole ratio of the precipitated
sulphur and amine derivatives. The synthesized thioamides derivatives were characterized by 1H and
13C NMR, FT IR, HRMS spectrometric techniques. This method has various advantages, including
high yields, a relatively rapid reaction time and the ability to operate in catalyst-free conditions.
Publisher
Asian Journal of Chemistry