p-TSA Catalyzed Synthesis of Tetrahydrobenzo[g]quinolines via Multicomponent Reaction using Pyrazole Aldehyde, Lawsone, β-Ketoesters and Ammonium Acetate

Abstract

An efficient protocol has been developed for the multicomponent synthesis of tetrahydrobenzo[g]quinoline-3-carboxylate derivatives using p-toluenesulfonic acid (p-TSA) as catalyst through one-pot four component condensation reaction of pyrazole aldehyde, Lawsone, β-ketoesters and ammonium acetate in ethanol. The synthesized compounds were characterized by spectroscopic techniques.