Main clinical variables related to long-term mortality in COVID-19

Abstract

Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months.  Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p<0.001) was higher in patients who died at 12 month follow-up compared to the surviving group. Age>70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.