COMPARATIVE STUDY OF EXTEMPORANEOUS MOUTHWASHES FOR MUCOSITIS: WORLD SITUATION AND PERSPECTIVES FOR UKRAINE

Abstract

Oral mucositis is one of the most common toxicities observed during radiotherapy and chemotherapy for patients with cancer. It is painful and significantly affect nutrition process and mouth care. Painful mucositis impairs the ability to eat and drink fluids and impacts quality of life. Mixed medication mouthwash is commonly used to prevent or treat oral mucositis in world’s medical practice. It is typically compounded by a pharmacy and most often contains anticholinergic agents (diphenhydramine), an anesthetic (lidocaine) and an antacid or mucosal coating agent (magnesium or aluminum hydroxide, kaolin, or sucralfate). The mixture may also contain an antibiotic or an antifungal medication (nystatin) and a corticosteroid. In comparison, assortment of compounded topical medications consisted of mostly dosage forms for applications with benzocaine (anestezine) oily solutions, antiseptics (chlorhexidine), antibiotic or an antifungal medication (nystatin), natural additions (infusion of medical herbs) and vitamins.So, this article presents an analysis of literature data and the assortment of the compounded mouthwashes in Ukraine and in the world. Perspectives for development of new formulas are proposed for Ukrainian pharmacies.