ACTOPROTECTOR ACTIVITY OF 4-R-(IDENEAMINO)- 5-R-4Н-1,2,4-TRIAZOLE-3-THIOLS-Reference-Cited by-同舟云学术

ACTOPROTECTOR ACTIVITY OF 4-R-(IDENEAMINO)- 5-R-4Н-1,2,4-TRIAZOLE-3-THIOLS

Published:2019-11-30 Issue:9(26) Volume: Page:23-26
ISSN:2544-9443
Container-title:Science Review
language:
Short-container-title:RS Global - Science Review

Author:

Hlazunova T. V. ,Panasenko O. I. ,Knysh Ye. H.

Abstract

In this study, actoprotector activity of 1,2,4-triazole derivatives is described. The biological activity of synthetic 4-R-(ideneamino)-5-R-4Н-1,2,4-triazole-3- thiols was analyzed. The forced swim test with a weight load of 10% of the test animal’s body weight was applied. According to the obtained results, compounds that contained NH4+ and CuSO4 substituents were among the most active, potency of which was close to that of the reference drug Riboxin. Introduction of propylamine, isopropylamine and piperazine groups into the molecule decreases the actoprotector activity. Compounds containing monoethanolamine, diethylamine, ethylamine, and magnesium sulfate moieties almost did not exhibit actoprotector activity.

Publisher

RS Global Sp. z O.O.

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