Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences

Author:

Rideout Jai Ram12,He Yan3,Navas-Molina Jose A.4,Walters William A.5,Ursell Luke K.6,Gibbons Sean M.78,Chase John9,McDonald Daniel410,Gonzalez Antonio10,Robbins-Pianka Adam410,Clemente Jose C.2,Gilbert Jack A.811,Huse Susan M.12,Zhou Hong-Wei3,Knight Rob1013,Caporaso J. Gregory19

Affiliation:

1. Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA

2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3. State Key Laboratory of Organ Failure Prevention, and Department of Environmental Health, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong, China

4. Department of Computer Science, University of Colorado Boulder, Boulder, CO, USA

5. Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO, USA

6. Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO, USA

7. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA

8. Institute for Genomics and Systems Biology, Argonne National Laboratory, Lemont, IL, USA

9. Department of Biological Sciences, Northern Arizona University, AZ, USA

10. BioFrontiers Institute, University of Colorado at Boulder, Boulder, CO, USA

11. Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA

12. Department of Pathology and Laboratory Science, Warren Alpert Medical School, Brown University, Providence, RI, USA

13. Howard Hughes Medical Institute, Boulder, CO, USA

Publisher

PeerJ

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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